{"id":18023,"date":"2023-02-17T11:42:10","date_gmt":"2023-02-17T16:42:10","guid":{"rendered":"https:\/\/www.myface.org\/?page_id=18023"},"modified":"2024-01-17T23:42:14","modified_gmt":"2024-01-18T04:42:14","slug":"crouzonsyndrome","status":"publish","type":"page","link":"https:\/\/www.myface.org\/es\/craniofacial-conditions\/crouzonsyndrome\/","title":{"rendered":"S\u00edndrome de Crouzon"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><div class=\"vc_row wpb_row vc_row-fluid\"><div class=\"wpb_column vc_column_container vc_col-sm-12\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\">\n\t<div class=\"wpb_raw_code wpb_raw_html wpb_content_element\" >\n\t\t<div class=\"wpb_wrapper\">\n\t\t\t<script type=\"application\/ld+json\">\n{\n        \"@context\": \"https:\/\/schema.org\/\",\n        \"@type\": \"MedicalCondition\",\n                \"name\":\"Crouzon Syndrome\",\n                \"alternateName\":\"Craniofacial dysostosis\",\n                \"associatedAnatomy\":{\n                      \"@type\": \"AnatomicalStructure\",\n                      \"name\": \"head\"},\n                \"description\":\"Crouzon syndrome is one of several types of craniosynostosis, a condition that results from premature fusion of one or more sutures of the skull bones.\",\n                \"url\":\"https:\/\/www.myface.org\/craniofacial-conditions\/crouzonsyndrome\/\",\n                \"sameAs\" : \"https:\/\/en.wikipedia.org\/wiki\/Crouzon_syndrome\",\n                \"signOrSymptom\":[\"Tall, flattened forehead\",\"Wide-set eyes (hypertelorism) which may appear as bulging or protruding (proptosis)\",\"Beak-shaped nose\"],\n                                \"possibleTreatment\": {\"@type\":\"medicalTherapy\",\"name\":\"Fronto Orbital Advancement\",\"url\":\"https:\/\/www.myface.org\/surgeries\/fronto-orbital-advancement\/\"}\n}\n<\/script>\n\t\t<\/div>\n\t<\/div>\n<div class=\"ult-spacer spacer-69defaae739aa\" data-id=\"69defaae739aa\" data-height=\"80\" data-height-mobile=\"80\" data-height-tab=\"80\" data-height-tab-portrait=\"\" data-height-mobile-landscape=\"50\" style=\"clear:both;display:block;\"><\/div><div id=\"ultimate-heading-406469defaae739e2\" class=\"uvc-heading ult-adjust-bottom-margin ultimate-heading-406469defaae739e2 uvc-6874 \" data-hspacer=\"no_spacer\"  data-halign=\"center\" style=\"text-align:center\"><div class=\"uvc-heading-spacer no_spacer\" style=\"top\"><\/div><div class=\"uvc-main-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-406469defaae739e2 h2'  data-responsive-json-new='{\"font-size\":\"desktop:46px;tablet:46px;tablet_portrait:46px;mobile_landscape:35px;mobile:35px;\",\"line-height\":\"\"}' ><h2 style=\"font-weight:bold;color:#ffffff;\">Crouzon Syndrome<\/h2><\/div><\/div><div class=\"ult-spacer spacer-69defaae73a08\" data-id=\"69defaae73a08\" data-height=\"80\" data-height-mobile=\"80\" data-height-tab=\"80\" data-height-tab-portrait=\"\" data-height-mobile-landscape=\"50\" style=\"clear:both;display:block;\"><\/div><\/div><\/div><\/div><\/div><!-- Row Backgrounds --><div class=\"upb_color\" data-bg-override=\"0\" data-bg-color=\"#00a4b4\" data-fadeout=\"\" data-fadeout-percentage=\"30\" data-parallax-content=\"\" data-parallax-content-sense=\"30\" data-row-effect-mobile-disable=\"true\" data-img-parallax-mobile-disable=\"true\" data-rtl=\"false\"  data-custom-vc-row=\"\"  data-vc=\"8.0\"  data-is_old_vc=\"\"  data-theme-support=\"enable\"   data-overlay=\"false\" data-overlay-color=\"\" data-overlay-pattern=\"\" data-overlay-pattern-opacity=\"\" data-overlay-pattern-size=\"\"    ><\/div><div class=\"vc_row wpb_row vc_row-fluid\"><div class=\"wpb_column vc_column_container vc_col-sm-12 vc_hidden-lg vc_hidden-md\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\">\n\t<div class=\"wpb_text_column wpb_content_element\" >\n\t\t<div class=\"wpb_wrapper\">\n\t\t\t<h3 style=\"color: #d8007e;\">In This Article<\/h3>\n<p><em>Click to jump to your selected section.<\/em><\/p>\n<p><a href=\"#whatis\"><strong>What is Crouzon Syndrome?<\/strong><\/a><\/p>\n<p><a href=\"#prevalance\"><strong>Prevalence<\/strong><\/a><\/p>\n<p><a href=\"#causes\"><strong>Causes<\/strong><\/a><\/p>\n<p><strong><a href=\"#Genetics\">Genetics<\/a><\/strong><\/p>\n<p><a href=\"#signs\"><strong>Signs &amp; Symptoms<\/strong><\/a><\/p>\n<p><a href=\"#eye\"><strong>Eye Abnormalities<\/strong><\/a><\/p>\n<p><a href=\"#apert\"><strong>Comparison to Apert Syndrome<\/strong><\/a><\/p>\n<p><a href=\"#diagnosing\"><strong>Diagnosis<\/strong><\/a><\/p>\n<p><a href=\"#treatments\"><strong>Treatments &amp; Procedures<\/strong><\/a><\/p>\n<p><a href=\"#living\"><strong>Living with Crouzon Syndrome<\/strong><\/a><\/p>\n<p><a href=\"#complications\"><strong>Potential Complications<\/strong><\/a><\/p>\n<p><a href=\"#meet\"><strong>Meet a member of the myFace Community<\/strong><\/a><\/p>\n<p><a href=\"#resources\"><strong>Resources for the Craniofacial Community<\/strong><\/a><\/p>\n<p><a href=\"#references\"><strong>References<\/strong><\/a><\/p>\n\n\t\t<\/div>\n\t<\/div>\n<\/div><\/div><\/div><div class=\"wpb_column vc_column_container vc_col-sm-8 vc_col-lg-offset-1 vc_col-lg-10 vc_col-md-offset-1 vc_col-md-10 vc_col-xs-12\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"vc_row wpb_row vc_inner vc_row-fluid\"><div class=\"wpb_column vc_column_container vc_col-sm-8\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\">\n\t<div class=\"wpb_text_column wpb_content_element\" >\n\t\t<div class=\"wpb_wrapper\">\n\t\t\t<p><strong><span style=\"text-decoration: underline;\"><a href=\"\/craniofacial-conditions\/\">Craniofacial Conditions<\/a><\/span><\/strong> &gt; <strong>Crouzon Syndrome<\/strong><\/p>\n\n\t\t<\/div>\n\t<\/div>\n\n\t<div class=\"wpb_text_column wpb_content_element\" >\n\t\t<div class=\"wpb_wrapper\">\n\t\t\t<div class=\"trp_language_switcher_shortcode\">\n<div class=\"trp-language-switcher trp-language-switcher-container\" data-no-translation >\n    <div class=\"trp-ls-shortcode-current-language\">\n        <a href=\"#\" class=\"trp-ls-shortcode-disabled-language trp-ls-disabled-language\" title=\"Espa\u00f1ol\" onclick=\"event.preventDefault()\">\n\t\t\t<img loading=\"lazy\" decoding=\"async\" class=\"trp-flag-image\" src=\"https:\/\/www.myface.org\/wp-content\/plugins\/translatepress-multilingual\/assets\/images\/flags\/es_ES.png\" width=\"18\" height=\"12\" alt=\"es_ES\" title=\"Espa\u00f1ol\"> Espa\u00f1ol\t\t<\/a>\n    <\/div>\n    <div class=\"trp-ls-shortcode-language\">\n                <a href=\"#\" class=\"trp-ls-shortcode-disabled-language trp-ls-disabled-language\"  title=\"Espa\u00f1ol\" onclick=\"event.preventDefault()\">\n\t\t\t<img loading=\"lazy\" decoding=\"async\" class=\"trp-flag-image\" src=\"https:\/\/www.myface.org\/wp-content\/plugins\/translatepress-multilingual\/assets\/images\/flags\/es_ES.png\" width=\"18\" height=\"12\" alt=\"es_ES\" title=\"Espa\u00f1ol\"> Espa\u00f1ol\t\t<\/a>\n                    <a href=\"https:\/\/www.myface.org\/es\/wp-json\/wp\/v2\/pages\/18023#TRPLINKPROCESSED\" title=\"English\">\n            <img loading=\"lazy\" decoding=\"async\" class=\"trp-flag-image\" src=\"https:\/\/www.myface.org\/wp-content\/plugins\/translatepress-multilingual\/assets\/images\/flags\/en_US.png\" width=\"18\" height=\"12\" alt=\"en_US\" title=\"English\"> English        <\/a>\n\n        <\/div>\n    <script type=\"application\/javascript\">\n        \/\/ need to have the same with set from JS on both divs. Otherwise it can push stuff around in HTML\n        var trp_ls_shortcodes = document.querySelectorAll('.trp_language_switcher_shortcode .trp-language-switcher');\n        if ( trp_ls_shortcodes.length > 0) {\n            \/\/ get the last language switcher added\n            var trp_el = trp_ls_shortcodes[trp_ls_shortcodes.length - 1];\n\n            var trp_shortcode_language_item = trp_el.querySelector( '.trp-ls-shortcode-language' )\n            \/\/ set width\n            var trp_ls_shortcode_width                                               = trp_shortcode_language_item.offsetWidth + 16;\n            trp_shortcode_language_item.style.width                                  = trp_ls_shortcode_width + 'px';\n            trp_el.querySelector( '.trp-ls-shortcode-current-language' ).style.width = trp_ls_shortcode_width + 'px';\n\n            \/\/ We're putting this on display: none after we have its width.\n            trp_shortcode_language_item.style.display = 'none';\n        }\n    <\/script>\n<\/div>\n<\/div>\n<h2><span style=\"color: #64bbcd;\">Crouzon Syndrome<\/span><\/h2>\n<h3 id=\"whatis\"><strong>What is Crouzon Syndrome?<\/strong><\/h3>\n<p>Crouzon syndrome is one of several types of craniosynostosis \u2013 a condition that results from the premature fusion of one or more of the seams (sutures) of the skull bones. This means that the cranial sutures, or the joints between the skull bones, have closed too early, resulting in skull and facial malformations.<\/p>\n<p>The condition was first described in 1912 by French physician Octave Crouzon, who observed patients with characteristic skull malformations, facial anomalies, and proptosis (bulging of the eyes from their normal position).<\/p>\n<h3 id=\"prevalance\"><strong>Prevalence of Crouzon Syndrome<\/strong><\/h3>\n<p><span style=\"font-weight: 400;\">Often considered the mildest form of the various craniosynostosis syndromes, Crouzon syndrome is estimated to occur in 1 in 60,000 newborns and appears to affect males more often than females. Crouzon syndrome accounts for about 5% of all craniosynostosis patients, and is the second most common craniosynostosis syndrome (out of over 100 such identified syndromes), affecting about 5,000 people in the United States.\u00a0<\/span><\/p>\n<h4>Crouzon Syndrome is often referred to as:<\/h4>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Craniofacial dysostosis\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Craniostenosis (Crouzon type)\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Crouzon craniofacial dysostosis<\/span><\/li>\n<\/ul>\n<hr \/>\n<h3 id=\"causes\"><strong>Causes of Crouzon Syndrome<\/strong><\/h3>\n<p><span style=\"font-weight: 400;\">Crouzon syndrome is a rare genetic disorder that is caused by mutations in the <\/span><span style=\"font-weight: 400;\">F<\/span><span style=\"font-weight: 400;\">ibroblast <\/span><span style=\"font-weight: 400;\">G<\/span><span style=\"font-weight: 400;\">rowth <\/span><span style=\"font-weight: 400;\">F<\/span><span style=\"font-weight: 400;\">actor <\/span><span style=\"font-weight: 400;\">R<\/span><span style=\"font-weight: 400;\">eceptor (<\/span><i><span style=\"font-weight: 400;\">FGFR)-2<\/span><\/i><span style=\"font-weight: 400;\"> and <\/span><i><span style=\"font-weight: 400;\">-3<\/span><\/i><span style=\"font-weight: 400;\"> genes, which are located on chromosome 10. More than 90% of Crouzon syndrome cases are caused by various mutations in the<\/span><i><span style=\"font-weight: 400;\"> FGFR-2 <\/span><\/i><span style=\"font-weight: 400;\">gene, in which 50 unique mutations have been identified to date. The remainder of cases are mostly caused by a specific mutation in <\/span><i><span style=\"font-weight: 400;\">FGFR-3<\/span><\/i><span style=\"font-weight: 400;\">, which is characteristically associated with acanthosis nigricans. Acanthosis nigricans symptoms include dark and thickened velvety skin which appears in body folds and creases, such as in the armpits and groin.<\/span><\/p>\n<h3 id=\"genetics\"><span style=\"font-weight: 800;\">Crouzon Syndrome and Genetics<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Both FGFR-2 and FGFR-3 are protein receptors that play a role in craniofacial bone formation: during embryonic development, these receptors are involved in the creation of osteoblasts, which are cells that are responsible for bone formation.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The mutated versions of these receptors are abnormally active and accelerate the differentiation of osteoblasts, which leads to the premature fusion of the sutures in the newborn\u2019s skull.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">For example, the fusion of the coronal and sagittal sutures causes the bones forming the forehead (frontal bones) to join prematurely to the sides of the skull (parietal bones).<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Although Crouzon syndrome is associated with mutations in the <\/span><i><span style=\"font-weight: 400;\">FGFR<\/span><\/i><span style=\"font-weight: 400;\">-2 or <\/span><i><span style=\"font-weight: 400;\">-3<\/span><\/i><span style=\"font-weight: 400;\"> genes, it can present in different ways in different patients; while some patients may appear largely unaffected, others may have severe anomalies. An individual can acquire a mutation in these genes in one of two ways. In about 50% of cases, patients inherit Crouzon syndrome in an autosomal dominant pattern. This means that they have inherited at least one copy of the mutated gene from one of their parents.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">In autosomal dominant conditions, children of an affected parent have a 50% chance of inheriting the condition. In the remaining cases, the mutation is the result of a \u201c<\/span><i><span style=\"font-weight: 400;\">de novo<\/span><\/i><span style=\"font-weight: 400;\">\u201d (\u201cnew\u201d) mutation, meaning it appears spontaneously for the first time in the affected individual, without any prior family history. The causes of these <\/span><i><span style=\"font-weight: 400;\">de novo<\/span><\/i><span style=\"font-weight: 400;\"> mutations are largely unknown, but some studies have suggested a link with advanced paternal age.<\/span><\/p>\n<hr \/>\n<h3 id=\"signs\"><strong>Signs &amp; Symptoms of Crouzon Syndrome<\/strong><\/h3>\n<p><span style=\"font-weight: 400;\">Premature fusion of cranial sutures (or \u201cjoints\u201d between the various bones of the skull) during the first year of life leads to restricted growth and development of the skull, face, brain, and central nervous system. Thus, the clinical features become increasingly apparent during the first 1-2 years of life and can progress until age three. However, there can still be variability in the presentation, as some patients may show prominent signs at birth, while others may not manifest any changes until early childhood. Some people with Crouzon syndrome may have very mild facial changes, while others are more severe.<\/span><\/p>\n<p style=\"text-align: center;\"><a href=\"https:\/\/www.myface.org\/craniofacial-conditions\/crouzonsyndrome\/signs\/\"><strong>Read more about the Signs &amp; Symptoms of Crouzon Syndrome \u2192<\/strong><\/a><\/p>\n<hr \/>\n<h3 id=\"eye\"><strong>Eye Abnormalities and Crouzon Syndrome<\/strong><\/h3>\n<p><span style=\"font-weight: 400;\">Ocular (eye) abnormalities are also frequently seen in Crouzon patients. Due to the early fusion of the sutures in the skull, the orbits (or eye sockets) are adversely affected. This causes the characteristic proptosis, or the protrusion of the eyeballs, seen in Crouzon patients. This can lead to dry eyes or excessive tearing and tends to make patients more susceptible to inflammation of the surface of the eye (keratitis) as well as conjunctivitis or \u201cpink eye.\u201d The abnormal orbital bone formation can result in an altered arrangement of the muscles behind the eyes, leading to strabismus (\u201ccrossed\u201d or misaligned eyes) as well as amblyopia (\u201clazy eye&#8221;).\u00a0<\/span><\/p>\n<h4><strong>Glaucoma and Crouzon<\/strong><\/h4>\n<p><span style=\"font-weight: 400;\">Crouzon patients are also at higher risk for conditions that affect vision such as refractive errors and glaucoma. Refractive errors occur when the eye is misshapen, which affects the ability of light from focusing appropriately onto the retina; examples of refractive errors are near- and far-sightedness as well as astigmatism. Another common vision problem is glaucoma, which occurs when there is an abnormality in the eye\u2019s drainage system. This can lead to the buildup of fluid and increased pressure inside the eye, which can ultimately result in damage to the optic nerve.<\/span><\/p>\n<hr \/>\n<h3 id=\"apert\"><strong>Comparison to Apert Syndrome<\/strong><\/h3>\n<p><span style=\"font-weight: 400;\">Although it shares overlapping features with other craniosynostosis syndromes such as <\/span><a href=\"https:\/\/www.myface.org\/craniofacial-conditions\/apert-syndrome\/\"><span style=\"font-weight: 400;\">Apert syndrome<\/span><\/a><span style=\"font-weight: 400;\"> or Pfeiffer syndrome, it is important to note that patients with Crouzon syndrome typically have normally formed hands and feet. Patients with Crouzon syndrome do not show syndactyly, which is the webbing of the fingers or toes, that is commonly seen in Apert syndrome. They also do not have short broad big toes or thumbs, which are characteristic of Pfeiffer syndrome.<\/span><\/p>\n<hr \/>\n<h3 id=\"diagnosing\"><strong>Diagnosing Crouzon Syndrome<\/strong><\/h3>\n<p><span style=\"font-weight: 400;\">It is possible to detect Crouzon Syndrome in a prenatal ultrasound, but it is more commonly diagnosed at birth or within the first year of life when the classic \u201ccrouzonoid features\u201d are observed.\u00a0<\/span><\/p>\n<h4><b>Physical signs of Crouzon Syndrome include:\u00a0<\/b><\/h4>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Craniosynostosis<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u00a0Midface Hypoplasia: underdevelopment of the eye sockets, cheekbones, and upper jaw\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u00a0Proptosis, or \u201cbulging eyes&#8221;<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u00a0Beaked Nose\u00a0<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">In patients with a known family history of Crouzon syndrome, these features are\u00a0 generally enough to confirm a diagnosis. However, in those with a spontaneous mutation, genetic testing and other imaging tests may be necessary, especially as the physical features may not be clear initially in the newborn.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Additional radiology tests may be needed to confirm the diagnosis including x-ray, CT, or MRI scans to image the bone structures and brain. If the diagnosis is still not confirmed based on history, clinical features, and imaging, molecular testing can be performed to assess whether the <\/span><i><span style=\"font-weight: 400;\">FGFR-<\/span><\/i><span style=\"font-weight: 400;\">2 or &#8211;<\/span><i><span style=\"font-weight: 400;\">3<\/span><\/i><span style=\"font-weight: 400;\"> mutations associated with Crouzon syndrome are present, which would help to distinguish it from other craniosynostosis syndromes.<\/span><\/p>\n<hr \/>\n<h3 id=\"treatments\"><strong>Crouzon Syndrome Treatments &amp; Procedures<\/strong><\/h3>\n<p><span style=\"font-weight: 400;\">Like many other craniofacial conditions, the management and treatment of Crouzon Syndrome depends on the features and severity of the appearance-related and functional impact on each individual patient. Aside from a pediatrician, a multidisciplinary team of craniofacial specialists, including oral maxillofacial surgeons, plastic surgeons, neurosurgeons, otolaryngologists (ENT), and ophthalmologists will likely be required to manage the patient.<\/span><\/p>\n<h4><strong>Surgical Interventions\u00a0<\/strong><\/h4>\n<p><span style=\"font-weight: 400;\">Surgical interventions are the main form of treatment for most children to prevent the most serious consequences of abnormal cranial development, including:\u00a0<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Increased intracranial pressure\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Blindness\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Intellectual disabilities\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hearing loss\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u00a0Respiratory and breathing problems\u00a0<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Generally, experts agree that early intervention before the age of 1 year results in lower risk of cognitive disabilities, airway obstruction, and visual problems. Surgery can take place in a staged or a combined approach.<\/span><\/p>\n<p style=\"text-align: center;\"><a href=\"https:\/\/www.myface.org\/craniofacial-conditions\/crouzonsyndrome\/treatments\/\"><b>Read more about Crouzon Syndrome Treatments &amp; Procedures\u00a0 \u2192<\/b><\/a><\/p>\n<hr \/>\n<h3 id=\"living\"><strong>Living with Crouzon Syndrome<\/strong><\/h3>\n<p><span style=\"font-weight: 400;\">With proper care, patients with Crouzon syndrome typically have normal life spans. However, some long-term functional issues and complications may still persist.<\/span><\/p>\n<h4><span style=\"font-weight: 900;\">Functional Challenges<\/span><\/h4>\n<p><span style=\"font-weight: 400;\">The three most common functional challenges related to Crouzon syndrome are visual impairment, breathing issues, and hearing loss, as follows:<\/span><\/p>\n<h4><span style=\"font-weight: 900;\">Visual Impairment<\/span><\/h4>\n<p><span style=\"font-weight: 400;\">Because of the orbital proptosis (or bulging of the eyes) in Crouzon syndrome, patients have difficulty protecting the eye, leading to an increased risk of damage, inflammation, or infection to the eye, which can result in loss of vision. Also, due to increased intracranial pressure, the optic nerve can develop edema or swelling, resulting in vision loss. Thus, ocular development needs to be monitored carefully in the long-term, and regular monitoring for increased intracranial pressure should be done by using ophthalmologic and radiology exams until at least age 8.<\/span><\/p>\n<h4><span style=\"font-weight: 900;\">Breathing Problems<\/span><\/h4>\n<p><span style=\"font-weight: 400;\">Due to the underdevelopment of the jaw structures, many patients can develop obstructive sleep apnea (OSA). Patients with obstructive sleep apnea can experience respiratory depression and decreased oxygenation during sleep.\u00a0<\/span><\/p>\n<p style=\"text-align: center;\"><a href=\"https:\/\/www.myface.org\/craniofacial-conditions\/crouzonsyndrome\/breathing\/\"><b>Read more about Breathing Problems associated with Crouzon Syndrome\u00a0 \u2192<\/b><\/a><\/p>\n<h4><span style=\"font-weight: 900;\">Hearing Loss<\/span><\/h4>\n<p><span style=\"font-weight: 400;\">Due to abnormal growth and shape of the skull in Crouzon syndrome, deafness can occur when neural signals from the inner ear cannot be transmitted to the brain properly. Also, patients with Crouzon syndrome and other similar syndromes are at increased risk for recurrent otitis media (or middle ear infections), which can result in hearing loss. Hearing loss can occur in up to 50% of patients with Crouzon syndrome. Thus, proper care with an audiologist and other specialists are needed to monitor hearing, especially for those with recurrent infections, and to ensure the patient has hearing aids and other assistive devices to support proper speech development, learning, and social and emotional development. Children may also need support from ongoing speech and language therapy.<\/span><\/p>\n<hr \/>\n<h3 id=\"complications\"><strong>Potential Complications of Crouzon Syndrome<\/strong><\/h3>\n<h4><strong>Increased intracranial pressure<\/strong><\/h4>\n<p><span style=\"font-weight: 400;\">Increase in the pressure inside the skull is the most serious complication of Crouzon syndrome, especially in the absence of a surgical intervention &#8211; such as open cranial vault remodeling &#8211; early in life to prevent this. In fact, in cases of untreated Crouzon syndrome, the incidence of increased intracranial pressure episodes has been reported to be almost 63%, with potential consequences for vision loss, blindness, and impaired cognitive development.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">In Crouzon syndrome, the causes of increased pressure in the skull include hydrocephalus (increased fluid in the brain), airway obstruction, and intracranial venous hypertension (increased blood pressure in the veins within the brain). On average, the first episode of increased intracranial pressure occurs around 1.4 years old, and about half of these patients go on to experience a second episode about 1.4 years after the initial episode. Once increased intracranial pressure is detected, urgent treatment should be initiated based on the cause.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">For example, in the case of hydrocephalus, a ventriculoperitoneal shunt can be placed to drain the excess fluid. If airway obstruction is the cause of increased intracranial pressure, the child may require an airway inserted into the nose and pharynx (a nasopharyngeal airway), initiation of continuous positive airway pressure to provide additional oxygenation, or may need to undergo surgery to remove the adenoids and tonsils to help open the airways. Lastly, if the cause is intracranial venous hypertension, the patient should be treated with a posterior vault expansion surgery (see above).<\/span><\/p>\n<h4><strong>Chronic neurologic conditions\u00a0<\/strong><\/h4>\n<p><span style=\"font-weight: 400;\">Patients with Crouzon syndrome may occasionally experience ongoing neurologic symptoms. For example, 25% of patients report having chronic headaches, and about 10% have recurring seizures or epilepsy. Chronic headaches can be associated with elevated intracranial pressure \u2013 but not always. In rare cases, it may also be caused by a persistent leakage of cerebrospinal fluid, which may have been caused by accidental puncture during spinal anesthesia during prior surgeries. The cause of seizures in Crouzon syndrome is unclear, but it may be related to the structural brain abnormalities caused by skull formation and hydrocephalus (excess fluid around the brain). Patients with seizures will need to be managed by a neurologist, who will use medications to minimize the occurrence of seizures as much as possible. Patients may only require one medication or sometimes combinations of medications to achieve adequate control.<\/span><\/p>\n<h4><strong>Mental and emotional health challenges<\/strong><\/h4>\n<p><span style=\"font-weight: 400;\">As in patients with other craniofacial anomalies, children with Crouzon syndrome may suffer from self-esteem and confidence issues related to their appearance and chronic medical conditions. Visual and hearing impairments may hinder their social interactions, and they may experience social isolation or even bullying. Thus, ongoing psychosocial support from social workers and psychologists are important to help children with Crouzon syndrome and their families maintain mental and emotional wellness throughout the time of diagnosis and ongoing treatment. Special services can also help children adjust socially and ensure effective learning at school.<\/span><\/p>\n<h4><strong>Developmental delay<\/strong><\/h4>\n<p id=\"meet\"><span style=\"font-weight: 400;\">Although most patients with Crouzon syndrome have normal intellectual ability, about 15% experience some mild to moderate developmental delay in their language, motor, or cognitive skills. Thus, the multidisciplinary treatment team should include a neuropsychologist who can evaluate a child for any developmental or cognitive delays and recommend interventions that can facilitate development.<\/span><\/p>\n<hr \/>\n<h3 id=\"meet\"><strong>Meet a Member of the myFace Community<\/strong><\/h3>\n<p style=\"text-align: left;\"><a href=\"https:\/\/www.myface.org\/more-than-meets-the-eye-lauren-sharaby\/\">Read Lauren\u2019s story \u2192<\/a><\/p>\n<hr \/>\n<h3 id=\"support\"><strong>myFace Provides Support for People Living with Crouzon Syndrome and Other Craniofacial Conditions<\/strong><\/h3>\n<p>myFace provides a variety of direct services and educational programs to help meet the needs of the craniofacial community, including:<\/p>\n<p><span style=\"font-weight: 400;\">myFace provides a variety of direct services and educational programs to help meet the needs of the craniofacial community, including:<\/span><\/p>\n<p><span style=\"font-weight: 400;\">(1)<\/span><span style=\"font-weight: 400;\"> \u00a0 <\/span><a href=\"https:\/\/www.myface.org\/online-groups\/\"><b><i>myFace Virtual Support Groups<\/i><\/b><\/a> <span style=\"font-weight: 400;\">provide counsel and community for individuals and their families living with facial differences. These help participants to feel safe, supported, and never alone. myFace offers Support Groups for adults, adolescents, and both English-speaking and Spanish-speaking parents.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">(2)<\/span><span style=\"font-weight: 400;\"> \u00a0 <\/span><a href=\"https:\/\/www.myface.org\/parent-guides\/\"><b><i>Parent Guides<\/i><\/b> <\/a><span style=\"font-weight: 400;\">provide resources and guidance to assist parents as they support their child\u2019s journey.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">(3) <\/span><a href=\"https:\/\/www.myface.org\/event-category\/webinars\/\"><b><i>Transforming Lives Webinar Series<\/i><\/b><\/a><span style=\"font-weight: 400;\"> offers webinars with craniofacial experts on topics of interest to the community.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">(4)<\/span><span style=\"font-weight: 400;\">\u00a0 <\/span><b><i>\u00a0<\/i><\/b><a href=\"https:\/\/www.myface.org\/mystory\/\"><b><i>myFace, myStory Podcast Series<\/i><\/b><\/a><span style=\"font-weight: 400;\"> offers monthly interviews and roundtable discussions on topics of interest to the craniofacial community.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">(5)<\/span><span style=\"font-weight: 400;\"> \u00a0 <\/span><a href=\"https:\/\/www.myface.org\/surgeries\/\"><b><i>myFace\u2019s Guide to Craniofacial Surgeries<\/i><\/b><\/a><span style=\"font-weight: 400;\"> serves as a guide to patients\u2019 surgical experience, providing in-depth information on some of the most common craniofacial surgeries.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">(6) <\/span><a href=\"https:\/\/www.myface.org\/category\/newsletters\/\"><b><i>myFace | Your Impact Newsletter<\/i><\/b><\/a><span style=\"font-weight: 400;\"> provides the community with regular updates.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">(7)<\/span><span style=\"font-weight: 400;\"> \u00a0 <\/span><a href=\"https:\/\/www.myface.org\/travel-housing\/\"><b><i>myFace Family Apartments<\/i><\/b><\/a> <span style=\"font-weight: 400;\">provide free housing for out-of-town families seeking treatment in New York City.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">(8)<\/span> <a href=\"https:\/\/www.myface.org\/wonder\/\"><b><i>myFace Wonder Project<\/i><\/b><\/a> <span style=\"font-weight: 400;\">School Assemblies provides students with the tools they need to unite against bullying and to implement acts of kindness in their schools and in their communities.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">(9) <\/span><a href=\"https:\/\/www.myface.org\/events\/?_ga=2.258084041.2145212307.1652043471-658099123.1620322976&amp;_gac=1.213649824.1649882795.EAIaIQobChMI4LGrnvSR9wIVyauGCh0exA5_EAAYAiAAEgLd_PD_BwE\"><b><i>myFace Events<\/i><\/b><\/a> <span style=\"font-weight: 400;\">provide opportunities for the craniofacial community to gather together.<\/span><\/p>\n<hr \/>\n<h3 id=\"references\"><strong><span lang=\"EN\">References<\/span><\/strong><\/h3>\n<ul>\n<li><span style=\"font-weight: 400;\">Abu-Sittah GS, Jeelani O, Dunaway D, Hayward R. Raised intracranial pressure in Crouzon syndrome: incidence, causes, and management. <\/span><i><span style=\"font-weight: 400;\">J Neurosurg Pediatr.<\/span><\/i><span style=\"font-weight: 400;\"> 2016; 17: 469-475.\u00a0 (Full online access:<\/span><a href=\"https:\/\/thejns.org\/pediatrics\/view\/journals\/j-neurosurg-pediatr\/17\/4\/article-p469.xml?tab_body=pdf-25465\"> <span style=\"font-weight: 400;\">https:\/\/thejns.org\/pediatrics\/view\/journals\/j-neurosurg-pediatr\/17\/4\/article-p469.xml?tab_body=pdf-25465<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/li>\n<li><span style=\"font-weight: 400;\">Al-Namnam NM, Hariri F, Thong MK, Rahman ZA. Crouzon syndrome. <\/span><i><span style=\"font-weight: 400;\">J Oral Biol Craniofac Res<\/span><\/i><span style=\"font-weight: 400;\">. 2019; 9(1): 37-39. (Full article online:<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6128172\/\"> <span style=\"font-weight: 400;\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6128172\/<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/li>\n<li><span style=\"font-weight: 400;\">Bhattacharjee K, Rehman O, Venkatraman, et al. Crouzon syndrome and the eye: an overview. <\/span><i><span style=\"font-weight: 400;\">Indian J Ophthalmol<\/span><\/i><span style=\"font-weight: 400;\">. 2022; 70(7): 2346-2354.<\/span><\/li>\n<li><span style=\"font-weight: 400;\">Conrady CD, Patel BC. Crouzon syndrome. StatPearls. Updated August 8, 2022.<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK518998\"> <span style=\"font-weight: 400;\">https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK518998<\/span><\/a><span style=\"font-weight: 400;\">. Accessed November 6, 2022.<\/span><\/li>\n<li><span style=\"font-weight: 400;\">Craniosynostosis syndromes. UpToDate. Reviewed October 2022.<\/span><a href=\"https:\/\/www.uptodate.com\/contents\/craniosynostosis-syndromes\"> <span style=\"font-weight: 400;\">https:\/\/www.uptodate.com\/contents\/craniosynostosis-syndromes<\/span><\/a><span style=\"font-weight: 400;\">. Accessed November 6, 2022.<\/span><\/li>\n<li><span style=\"font-weight: 400;\">Crouzon syndrome. Boston Children\u2019s Hospital.<\/span><a href=\"https:\/\/www.childrenshospital.org\/conditions\/crouzon-syndrome\"> <span style=\"font-weight: 400;\">https:\/\/www.childrenshospital.org\/conditions\/crouzon-syndrome<\/span><\/a><span style=\"font-weight: 400;\">. Accessed November 6, 2022.<\/span><\/li>\n<li><span style=\"font-weight: 400;\">Crouzon syndrome. NORD.<\/span><a href=\"https:\/\/rarediseases.org\/rare-diseases\/crouzon-syndrome\/\"> <span style=\"font-weight: 400;\">https:\/\/rarediseases.org\/rare-diseases\/crouzon-syndrome\/<\/span><\/a><span style=\"font-weight: 400;\"> Accessed November 6, 2022.<\/span><\/li>\n<li><span style=\"font-weight: 400;\">Crouzon syndrome. NIH Genetic and Rare Diseases Information Center.<\/span><a href=\"https:\/\/rarediseases.info.nih.gov\/diseases\/6206\/crouzon-syndrome\"> <span style=\"font-weight: 400;\">https:\/\/rarediseases.info.nih.gov\/diseases\/6206\/crouzon-syndrome<\/span><\/a><span style=\"font-weight: 400;\">. Accessed November 6, 2022.<\/span><\/li>\n<li><span style=\"font-weight: 400;\">De Jong T, Toll MS, de Gier HHW, et al. Audiologic profile of children and young adults with syndromic and complex craniosynostosis. <\/span><i><span style=\"font-weight: 400;\">Arch Otolaryngol Head Neck Surg<\/span><\/i><span style=\"font-weight: 400;\">. 2011; 137(8): 775-778. (Full article online:<\/span> <a href=\"https:\/\/jamanetwork.com\/journals\/jamaotolaryngology\/fullarticle\/1106416\"><span style=\"font-weight: 400;\">https:\/\/jamanetwork.com\/journals\/jamaotolaryngology\/fullarticle\/1106416<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/li>\n<li><span style=\"font-weight: 400;\">Ko JM. Genetic syndromes associated with craniosynostosis.<\/span><i><span style=\"font-weight: 400;\"> J Korean Neurosurg Soc<\/span><\/i><span style=\"font-weight: 400;\">. 2016; 59(3): 187-191. (Full article online:<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4877538\"> <span style=\"font-weight: 400;\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4877538<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/li>\n<li><span style=\"font-weight: 400;\">McCarthy JG, Warren SM, Bernstein J, Burnett W, Cunningham ML, Edmond JC, et al. Parameters of care for craniosynostosis. <\/span><i><span style=\"font-weight: 400;\">Cleft Palate Craniofac J. <\/span><\/i><span style=\"font-weight: 400;\">2012;49:1S\u201324S<\/span><\/li>\n<li><span style=\"font-weight: 400;\">Surgery for syndromes: surgical procedures for craniofacial syndromes.<\/span><a href=\"https:\/\/www.seattlechildrens.org\/clinics\/craniofacial\/services\/surgery-for-syndromes\/\"> <span style=\"font-weight: 400;\">https:\/\/www.seattlechildrens.org\/clinics\/craniofacial\/services\/surgery-for-syndromes\/<\/span><\/a><span style=\"font-weight: 400;\"> Accessed December 3, 2022.<\/span><\/li>\n<\/ul>\n\n\t\t<\/div>\n\t<\/div>\n<\/div><\/div><\/div><div class=\"wpb_column vc_column_container vc_col-sm-4 vc_hidden-sm vc_hidden-xs\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"ult_row_spacer\"><div class=\"ult-sticky-anchor\"><div class=\"ult-sticky-section ult-sticky \"  data-gutter= '40' data-stick_behaviour= 'stick_with_scroll_row'  data-sticky_position= 'top' data-mobile='no' data-support='no'>\n\t<div class=\"wpb_text_column wpb_content_element\" >\n\t\t<div class=\"wpb_wrapper\">\n\t\t\t<h3 style=\"color: #d8007e;\">In This Article<\/h3>\n<p><em>Click to jump to your selected section.<\/em><\/p>\n<p><a href=\"#whatis\"><strong>What is Crouzon Syndrome?<\/strong><\/a><\/p>\n<p><a href=\"#prevalance\"><strong>Prevalence<\/strong><\/a><\/p>\n<p><a href=\"#causes\"><strong>Causes<\/strong><\/a><\/p>\n<p><strong><a href=\"#Genetics\">Genetics<\/a><\/strong><\/p>\n<p><a href=\"#signs\"><strong>Signs &amp; Symptoms<\/strong><\/a><\/p>\n<p><a href=\"#eye\"><strong>Eye Abnormalities<\/strong><\/a><\/p>\n<p><a href=\"#apert\"><strong>Comparison to Apert Syndrome<\/strong><\/a><\/p>\n<p><a href=\"#diagnosing\"><strong>Diagnosis<\/strong><\/a><\/p>\n<p><a href=\"#treatments\"><strong>Treatments &amp; Procedures<\/strong><\/a><\/p>\n<p><a href=\"#living\"><strong>Living with Crouzon Syndrome<\/strong><\/a><\/p>\n<p><a href=\"#complications\"><strong>Potential Complications<\/strong><\/a><\/p>\n<p><a href=\"#meet\"><strong>Meet a member of the myFace Community<\/strong><\/a><\/p>\n<p><a href=\"#resources\"><strong>Resources for the Craniofacial Community<\/strong><\/a><\/p>\n<p><a href=\"#references\"><strong>References<\/strong><\/a><\/p>\n\n\t\t<\/div>\n\t<\/div>\n<\/div><div class=\"ult-space\"><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"<p><a class=\"sd-more sd-all-trans\" href=\"https:\/\/www.myface.org\/es\/craniofacial-conditions\/crouzonsyndrome\/#more-18023\">Leer m\u00e1s<\/a><\/p>","protected":false},"author":21,"featured_media":0,"parent":11228,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"full-width-page.php","meta":{"footnotes":""},"class_list":["post-18023","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - 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